Can experimental peptides really accelerate recovery, enhance metabolism or slow down aging? Well, if we apply the same logic that is used to evaluate literally every other investigational drug (i.e., controlled, decently sized trials in humans) then the answer is quite sobering. In this video, we discuss the recent developments on peptide compounding, the potential risks, and the (primarily non-clinical) studies available for the six peptides at the center of the most recent boom: BPC-157, TB-500, KPV, Epitalon, MOTS-c and Semax.
Disclaimer: This video is provided for general informational and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider.
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Key literature references:
– Key reporting: FDA Advisory Committee’s Vote May Open A Drug-Compounding Back Door For Unapproved Peptides | Health Affairs
– Safety and Risk Assessment of No-Prescription Online Semaglutide Purchases; JAMA Network Open. 2024;7(8):e2428280
– PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation; Gastroenterology 2007, 134, 166
– Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model; Cell. Mol. Gastroenterol. Hepatol. 2016, 2, 340
– Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing; Curr Rev Musculoskelet Med. 2025, 18, 611
– Stable Gastric Pentadecapeptide BPC 157 and Wound Healing; Frontiers in Pharmacology 2021,12, 627533
– Emerging Use of BPC-157 in Orthopaedic Sports Medicine; Musculoskeletal Journal of Hospital for Special Surgery 2025, 21, 485
– Thymosin 4 promotes angiogenesis, wound healing, and hair follicle development; Mechanisms of Ageing and Development 2004, 125, 113
– Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study; Joint Diseases and Related Surgery 2026, 37, 822
– Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging; Biogerontology 2006, 142, 356
– The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance; Cell Metabolism 2015, 21, 443
– MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis; Nature Communications 2021, 12, 470
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Am I too conservative? What do you think aboout the HHS decision (and yes, typo in 00:45!)
Excellent video
Peptides are the equivalent of Ooze in TMNT. See the first and second live action movies to see how that ended…
I am afraid that after a covid-19 "vax" that probably killed more than Covid did, the false assertion of safety and efficacy when they were neither, I'm not convinced the FDA's oversight is for any purpose other to insure corporate profits, and I suspect that is your purpose as well.
…..❤….❤So much value in this video, appreciate it.🎉😂
My brother snorted a fat line of BPC500 thinking it was fentanyl and died of an overdose. Peptide laced fentanyl, not even once.
This channel never disappoints.
How many people have died from peptides?
After answering that question, answer the same question but with Panadol.
almost peak freedom. I think that's when they figure out how to shake and bake it. and no, too conservative is an oxymoron you're just rational and sane.
When something works, there's always somebody that wants to cut it down or make it seem as though it doesn't do its job, he's probably a certified doctor
The fear mongering around “peptides” is ridiculous if you do even a little bit of digging up, but becomes super suspicious when you find out Eli Lilly is doing everything they can so people won’t find out that exact versions of their products can be bought for 1-5% of their price. Including, hypothetically, paying a hoard of content creators.
You clearly don’t know anything about LL 37.
HQ video bro !
These have been available to the “gym bros for over a decade all from Chinese manufacturers and are still buying them and why if they don’t work? Gym bros are not the type of people to use shit that doesn’t work if you havnt noticed
I work as a senior scientist for a company manufacturing peptides under GMP and seeing this makes me nervous. You are not to conservative, this can be really dangerous
After a long day at work, it's very nice to see a video of such detail and quality pop up in my recommendations.
Thank you sir, for the very interesting and well-made content, over the years!
Why is the research conducted at Saint Petersburg University not treated with the same respect? Is it because more than half of U.S. adults reportedly read below a sixth-grade level, with recent estimates placing the figure at 54% among Americans aged 16 to 74? Or is it because of American expansionist and chauvinistic attitudes? This entire video comes across as condescending, dismissive, and unempathetic. I am disappointed in the elitist turn, this channel has taken, you no longer hear from me that is for sure.
new vid!!! let's gooo
Turns out all of these peptides promote muscle growth in brainworms
great work as always. by the way I'm a lipid specialist/synthetic chemist. If you ever need a perspective I'd be happy to help
its great to see an actually well researched and scientifically valid video on this topic
Man how you always post peak vids. Can you do a vid on psychotridine and hodgkinsine pls? pyrrolidinoindoline oligomers are just peak interesting.