Same woman, 13 kilos down after a strict diet. Now she has to keep them off for a year: with exercise, a daily weight-loss shot, both, or nothing. A year in, the shot is ahead of exercise. Then everything stops, and a year later they all step on the scale again. A real experiment with 195 people shows what the second weigh-in found.
Also in this video: what exercise did that the shot didn’t (body fat, blood sugar, hip bone density), the costs that showed up with the shot alone, why the hunger likely comes back when a GLP-1 drug stops, and how much exercise it actually took. The shot here is liraglutide (Saxenda), an older daily cousin of semaglutide (Ozempic, Wegovy).
SOURCES
1. Lundgren JR, et al. Healthy weight loss maintenance with exercise, liraglutide, or both combined. N Engl J Med. 2021;384(18):1719-1730.
2. Jensen SBK, et al. Bone health after exercise alone, GLP-1 receptor agonist treatment, or combination treatment: a secondary analysis of a randomized clinical trial. JAMA Netw Open. 2024;7(6):e2416775.
3. Jensen SBK, et al. Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: a post-treatment analysis of a randomised placebo-controlled trial. eClinicalMedicine. 2024;69:102475.
4. Sumithran P, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011;365(17):1597-1604.
The trial was funded in part by the Novo Nordisk Foundation; Novo Nordisk A/S supplied the liraglutide and placebo pens.
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The Shadow Trials: real studies, played out.
This video is for education only and is not medical advice. Talk to your doctor before changing medication, diet or training.
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